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Disease variant prediction with deep generative models of evolutionary data
We learn a distribution over protein sequences with Bayesian VAEs which we then leverage to predict the effects of mutations in human proteins.
Jonathan Frazer, Pascal Notin, Mafalda Dias, Aidan N. Gomez, Joseph K. Min, Kelly Brock, Yarin Gal, Debora S. Marks
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Disease variant prediction with deep generative models of evolutionary data