Virus; Protein; Escape prediction; Generative modeling

Viral Evolution and Antibody Escape Mutations using Deep Generative Models

We use the epistemic uncertainty of the VAE decoder to guide the optimization of properties of high-dimensional structured objects (e.g., molecules) in latent space.

Nicole Thadani, Nathan Rollins, Sarah Gurev, Pascal Notin, Yarin Gal, Debora Marks