Protein; Conformations; Cooperativity; High-throughput assay; Protein design

Large-scale discovery, analysis, and design of protein energy landscapes

Állan J. R. Ferrari, Sugyan M. Dixit, Jane Thibeault, Mario Garcia, Scott Houliston, Robert W. Ludwig, Pascal Notin, Claire M. Phoumyvong, Cydney M. Martell, Michelle D. Jung, Kotaro Tsuboyama, Lauren Carter, Cheryl H. Arrowsmith, Miklos Guttman, Gabriel J. Rocklin

Preprint. A multiplexed experimental approach to analyze conformational fluctuations across thousands of protein domains, revealing hidden variations that affect protein cooperativity and function.